Degenerative disc disease is a term used to describe age-related changes that occur in the soft discs present between the vertebral bones of the spine. These discs absorb stress and permit movement of the spine. Disc degeneration can lead to pain, limitation of movement and other symptoms. It is usually more pronounced in the region of the neck and lower back. Most cases of degenerative disc disease are treated conservatively. Surgery usually involves removal of the disc and fusion of adjacent vertebrae.